About Close Quarter Battle (CQB) Carbine:

• The 56 x 45 mm CQB Carbine is an indigenously designed, developed and manufactured (IDDM) compact firearm.
• It has been designed by DRDO’s Armament Research & Development Establishment (ARDE), Pune, and is being manufactured by Bharat Forge Ltd (a Pune based Indian multinational).
• CQB carbines are compact, lightweight weapons designed specifically for urban warfare, close-range engagements and counter-terrorism
• Their reduced size compared to standard rifles offers enhanced manoeuvrability in confined spaces whilst maintaining operational effectiveness.
• It has an effective range of 200 meters.
• The weapon also uses a 30-round curved magazine to ensure reliable feeding during rapid fire.
• It can fire both NATO-standard and INSAS ammunition.

About Oreshnik Missile:

• It is a Russian-made intermediate-range nuclear-capable ballistic missile.
• It was first launched operationally in 2024, in a precision strike targeting the Pivdenmash defence-industrial facility in Dnipro, Ukraine.
• Features:
  • It is mounted on a mobile transporter and launcher for rapid deployment and concealment.
  • It has an estimated range range of 5,000 kilometres.
  • Equipped with Multiple Independently Targetable Re-entry Vehicles (MIRVs), the “Oreshnik” can carry six to eight warheads, conventional or nuclear, hitting multiple targets simultaneously.
  • It is a hypersonic missile, capable of reaching speeds up to Mach 10.

About Bomb Cyclone:

• It is a large midlatitude storm resulting from explosive cyclogenesis (or, informally, bombogenesis), a type of accelerated extratropical cyclone development in which surface pressure falls substantially over a 24-hour
• In structure, a bomb cyclone is indistinguishable from any other intense midlatitude storm.
  • The center of the storm is a low-pressure cell (or cyclone) that draws winds near the surface inward.
• However, a bomb cyclone is set apart by its rapid rate of intensification. The intensification required to classify as "bombogenesis" varies by latitude.
• Bomb cyclones are often associated with atmospheric rivers and typically form in winter when cold and warm air masses collide.
• The four most active regions where extra-tropical explosive cyclogenesis occurs in the world are
  • the Northwest Pacific
  • the North Atlantic
  • the Southwest Pacific
  • the South Atlantic
• The precipitation associated with a bomb cyclone is intense, ranging from heavy downpours to strong thunderstorms to blizzards and heavy snowfalls, along with strong winds.

About Nimesulide:

• First introduced in Italy in 1985, it is a non-steroidal anti-inflammatory drug (NSAID) used for its pain-relieving, anti-inflammatory, and fever-reducing effects.
• It is commonly used to manage acute pain, musculoskeletal disorders, dental pain, and symptoms associated with conditions such as osteoarthritis and dysmenorrhea.
• Nimesulide works by inhibiting the action of cyclooxygenase (COX), an enzyme responsible for the production of prostaglandins-chemicals that cause pain, inflammation, and fever.
• By blocking this enzyme, Nimesulide reduces the levels of prostaglandins, thus providing relief from pain and inflammation.
• By targeting the underlying inflammatory process rather than just masking the pain, it helps relieve swelling, improves mobility and functions in affected areas, and enhances overall comfort and quality of life.
• Side Effects:
  • Long-term usage may harm the liver or result in significant side effects, including gastrointestinal bleeding or renal issues.
  • Apart from this, other side effects like sour stomach, dizziness, skin infection, diarrhoea, and increased liver enzymes might be observed in individuals.
• Regulation:
  • From its early years, nimesulide attracted safety concerns and was never approved for use in countries including the United States, the UK, Canada, Australia, New Zealand, and Japan.
  • In 2008, the International Society of Drug Bulletins, a WHO-supported network, called for a global ban on nimesulide.
  • India banned the use of nimesulide in children below 12 years of age in 2011 but continued to allow its use in older patients. However, concerns have persisted.

About Sirkeer Malkoha:

• The sirkeer malkoha, or sirkeer cuckoo, is a special type of cuckoo bird.
• Scientific Name: Taccocua leschenaultii
• Unlike some cuckoos, it does not lay its eggs in other birds' nests.
• Distribution: This species is widespread across the sub-Himalayan Indian subcontinent, extending into Bangladesh, Sri Lanka, and, more patchily, into Pakistan and Rajasthan.
• Habitat: It is typically found in scrub and thin forest habitats, often favoring hilly terrain.
• Features:
  • These birds have special feet called zygodactyle feet. This means two toes point forward and two point backward. This helps them grip branches and move on the ground.
• Conservation Status:
  • IUCN Red List: Least Concern.

About Bulgaria:

• Location: It is located in the south eastern region of the European continent, occupying the eastern part of the Balkan Peninsula.
• Bordering Countries: It is bordered by Romania, Turkey, Greece, Macedonia and Serbia.
• Maritime Border: It is bounded by the Black Sea in the east.
• Capital City: Sofia
• Geographical Features of Bulgaria:
  • Mountain Ranges: The Balkan Mountains cut across the central part of the country, while the Rhodope Mountains run through southern Bulgaria, along its border with Greece.
  • Highest Point: Musala Mt, located in the Rila Mountains.
  • Major Rivers: Major rivers include the Danube River, Iskur, Maritsa, Struma, Tundzha and Yantra rivers.
  • Climate: Most of Bulgaria has a moderate continental climate, which is tempered by Mediterranean influences in the south. 
  • Natural Resources: Bauxite, Copper, lead, zinc, coal etc.

What is Eurozone?

• The eurozone, or officially the euro area, refers to the geographic and economic region comprising those members of the European Union that have fully adopted the euro as their official currency.

About Pralay Missile:

• It is an indigenously developed short-range, surface-to-surface
• Features of Pralay Missile:
  • It is a solid propellant quasi-ballistic.
  • It is capable of carrying multiple types of warheads against various targets.
  • Range: The missile has a range of 150-500 km and can be launched from a mobile launcher.
  • The missile is capable of carrying conventional warheads.
  • It is equipped with guidance systems that provide a Circular Error Probable (CEP) of less than 10 meters.
  • Speed: It reaches terminal speeds of Mach 6.1 and can engage targets such as radar installations, command centers, and airstrips.
  • It has the ability to change its path after covering a certain range midair.
• Developed by: It has been developed by Research Centre Imarat and in collaboration with other Defence Research & Development Organisation labs.
• Industry partners: Bharat Dynamics Limited & Bharat Electronics Limited and many other industries and MSMEs.

About Stingless Bees:

• Stingless Bees are a class of bees which either do not have stingers or have stingers that cannot cause much pain.
• Common genera of stingless bees: Austroplebeia, Melipona, and Tetragonula.
• Defence Mechanism: They do possess stingers, but they are too small to be useful in defense. Instead of stinging, stingless bees use their mandibles to bite their attackers.
• Stingless bees are among the planet’s oldest pollinators, with a remarkable concentration of species in the Amazon rainforest.
• Distribution: They are found in tropical regions across the world, and about half of the 500 known species live in the Amazon.
  • Africa, Australia, Southeast Asia, and parts of the Americas are the main areas where the stingless bee is found. 
  • In India, these bees are reported primarily from the northeastern, eastern, and southern Indian States.
• Benefits: Stingless bees can be used for pollination without fear of being stung. They are known for their popular medicinal honey and pollination potential.
• Threats: Deforestation has reduced nesting sites, while pesticide use, climate change and competition from invasive honeybees have further weakened populations.

About PathGennie:

• It is a novel computational framework developed by scientists can significantly accelerate the simulation of rare molecular events.
• It is open source software developed for fast tracking of drug discovery by accurately tracking molecular unbinding pathways.
• It addresses a long-standing challenge in molecular simulations — accurately modelling how drug molecules detach from their target proteins.
  • This process, known as ligand unbinding, plays a key role in determining a drug’s “residence time”, which is often more relevant to therapeutic effectiveness than binding strength alone.
• It predicts the potential drugs unbind from their protein targets without the artificial distortions commonly used in standard methods.
• It mimics natural selection on a microscopic scale instead of forcing the molecule to move.
• Features of PathGennie:
  • It captures rare molecular events without artificial acceleration.
  • It generates multiple competitive unbinding pathways.
  • It estimates residence time of drug molecules.
  • It eliminates bias introduced by external force-based simulations.
• Potential Applications:
  • It addresses problems such as chemical reactions, catalytic processes, phase transitions or self-assembly phenomena.
  • It is also compatible with modern machine-learning techniques which ensures integrated into diverse simulation pipelines.