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Amyotrophic Lateral Sclerosis

Nov. 27, 2025

A research paper highlighted that number of cases of Amyotrophic Lateral Sclerosis (ALS) in the world will increase from 222,801 in 2015 to 376,674 in 2040, representing an increase of 69%.

About Amyotrophic Lateral Sclerosis:

  • It is also known as Lou Gehrig’s disease. It is a progressive neurological disorder that affects muscle movement.
  • It can occur at any age but symptoms commonly develop between the age of 55 and 75. The men are more likely to develop the condition.
  • Causes: In few people with ALS, a genetic cause can be identified.
  • How does ALS affect the body?
    • In people with ALS, the motor neurons degenerate and die and messages sent by the brain do not reach the muscles which results into muscles atrophy (lose strength and become weak).
    • Eventually, the brain loses control over voluntary movements including walking, chewing and even breathing, as the condition progresses. 
  • Symptoms and progression of ALS:
    • It includes muscle twitches in the arms, leg, shoulders or tongue; muscle cramps;
    • Tightness or stiffness of muscles; muscle weakness in a limb or the neck; and difficulty in chewing or swallowing. 
  • Treatment for Amyotrophic Lateral Sclerosis:
    • There is no treatment to reverse nerve degeneration, but some therapy may help to delay progression.
      • A treatment would include physical, occupational and speech therapy to improve quality of life.

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