Caterpillar fungus

Nov. 10, 2024

New research into a chemical produced by a caterpillar fungus that has shown promise as a possible cancer treatment has revealed how it interacts with genes to interrupt cell growth signals.

About Caterpillar fungus:

  • Caterpillar fungus (Ophiocordyceps Sinensis) is a fungal parasite of larvae (caterpillars) that belongs to the ghost moth.
  • It is endemic to the Tibetan Plateau, including the adjoining high Himalaya (3,200-4,500 metres above sea level).
  • It is locally known as Kira Jari (in India), Yartsagunbu (in Tibet), Yarso Gumbub (Bhutan), Dong Chong Xia Cao (China) and Yarsagumba (in Nepal).
  • In the Indian Himalayas, the species has been documented in the region from the alpine meadows of protected areas such as Nanda Devi Biosphere Reserve, Askot Wildlife Sanctuary, Kanchendzonga Biosphere Reserve and Dehan-Debang Biosphere Reserve.
  • Conservation status
    • IUCN: Vulnerable

What researchers found?

  • The chemical Cordycepin, interrupts the cell growth signals that are overactive in cancer, an approach that could be less damaging to healthy tissues than most currently available treatments.
  • Cordycepin is converted to cordycepin triphosphate, and this molecule was found to directly affect cancer cells.