Researchers at the National Institute of Animal Biotechnology (NIAB) found that reducing the activity of a cellular protein called ‘Cathepsin B’ (Cat B) helps preserve the ovarian reserve.
About Cathepsin B:
It is a lysosomal cysteine protease.
It is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins.
It is integrated into almost all lysosome-related processes, including protein turnover, degradation, lysosome-mediated cell death, antigen processing and apoptosis.
It degrades extracellular matrix proteins like collagen and fibronectin.
Role in Disease: It is involved in neuropathological and neurodegenerative diseases such as dementia, Alzheimer's disease, and traumatic brain injury.
What is ovarian reserve?
This ovarian reserve is the finite pool of egg cells (oocytes) that female mammals are born with. Unlike sperm, these crucial egg cells cannot be regenerated.
Over time, the quantity and quality of these eggs naturally decline due to factors like oxidative stress, inflammation and general cellular wear.
This process accelerates with age. ‘Cat B,’ a protein-degrading enzyme, seems to be a key driver of this decline.
By lowering its levels, we may be able to delay egg loss, effectively extending fertility naturally.
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