Cy-TB Test

July 22, 2025

Recently, the Kerala health authorities have introduced a test called Cy-TB for detecting and treating tuberculosis (TB) infection following the prioritisation of latent TB infection treatment under the National TB Elimination Programme (NTEP).

About Cy-TB Test:

  • It is a new intradermal test for detecting and treating tuberculosis (TB) infection.
  • It is a third-generation test approved by the Central TB Division, Government of India.
  • It is the current recommendation for use of the Cy-tb skin test under the NTEP program for age 18 years and above.
  • How does it work?
    • Cy-TB is a highly specific, accurate and user-friendly skin test, wherein 0.1 ml doses of tuberculosis-specific antigens (ESAT-6 and CFP-10) are injected into the skin in the inner forearm.
    • An induration (a raised area) of 5 mm or more which develops on the skin within 48-72 hours indicates TB infection.

What is TB?

  • TB is caused by bacteria (Mycobacterium tuberculosis) and it most often affects the lungs. TB is spread through the air when people with lung TB cough, sneeze or spit. A person needs to inhale only a few germs to become infected.
  • According to the World Health Organization’s Global Tuberculosis Report 2024, India continues to lead in the global TB burden (26% of cases) and is also the hub for drug-resistant TB (DR-TB) and TB deaths.
  • TB is the leading cause of death of people with HIV and also a major contributor to antimicrobial resistance.

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