FINDER OF RARE ENTITIES (FiRE)

Dec. 30, 2018

Delhi-based researchers have developed a new algorithm — Finder of Rare Entities (FiRE) —to make it easy to find rare cells from a very large pool of cells in a matter of seconds.

About:

  • The algorithm — Finder of Rare Entities (FiRE) — assigns a rareness score to each cell that is computed based on the gene expression profile of about twenty thousand genes.

  • Cells having scores above a certain threshold are reported as rare cells. Circulating tumour cells, cancer stem cells, antigen-specific T cells are a few examples of rare cells.

  • Significance:
    • It can find rare cells from a very large pool of cells in a matter of seconds.

    • Besides being fast, the new algorithm has superior sensitivity and specificity compared with existing methods.



Source : The Hindu

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