Researchers at ACTREC-Tata Memorial Centre have identified the presence of a bacteria, Fusobacterium nucleatum, in the oral tumours at a significantly higher burden than in the oral cavity of healthy individuals.
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Interestingly, Fusobacterium nucleatum is known to play a vital role in colorectal cancer, wherein its presence affects the spread of the disease and the patient's response to chemotherapy. However, a similar role of Fusobacterium in oral cancer was not known earlier.
The presence of the bacteria was found in Indian and Caucasian oral cancer patients, with a much higher incidence among the Indian patients.
Moreover, oral cancer patients positive for Fusobacterium were found to be negative for Human Papillomavirus (HPV) infection, suggesting they are present in a mutually exclusive way.
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