Hemochromatosis

About Hemochromatosis:

• It is an inherited condition where iron levels in the body slowly build up over many years.
• This health condition is primarily classified into two types:
  • Hereditary hemochromatosis: It is driven by a mutation in the HFE gene, resulting in individuals being homozygous for the C282Y variant.
  • This genetic anomaly sets the stage for a lifelong struggle with excessive iron absorption within the intestines.
  • Secondary hemochromatosis: It is typically caused by external factors like frequent blood transfusions, excessive iron supplementation, or certain medical conditions.
  • The iron accumulation in secondary hemochromatosis is often more rapid and can have a similar impact on organ function
• Symptoms of haemochromatosis usually start between the ages of 30 and 60.
• Common symptoms include: Feeling very tired all the time (fatigue), weight loss, weakness and joint pain etc
• Treatment:
  • Phlebotomy is the standard treatment for primary hemochromatosis.
  • Iron toxicity can be reduced by removing red blood cells, the body's main mobilizer of iron.
  • Phlebotomy is usually performed once or twice a week.