Smart Insulin (NNC2215)

About Smart Insulin (NNC2215):

• The newly developed insulin named NNC2215 comprises two parts: a ring-shaped structure, and a molecule with a similar shape to glucose called a glucoside. 
• How does it work?

• When blood sugar levels are low, the glucoside binds to the ring, keeping the insulin in an inactive state to prevent further lowering of blood sugar. 
• But, as blood glucose rises, the glucoside is replaced by glucose itself, triggering the insulin to shift its shape and become active, helping bring blood sugar levels down to safer ranges.

• Researchers who developed NNC2215 found it to be as effective as human insulin at lowering blood glucose in rats and pigs. 

Diabetes 

• Diabetes is a chronic disease that occurs when the pancreas can no longer make insulin, or the body cannot make good use of the insulin it produces.
• Insulin is a hormone that regulates blood glucose.
• Types of Diabetes 

• Type 1 diabetes: It often starts in childhood, occurs when the pancreas do not produce insulin (or enough insulin). 
• Type 2 diabetes: It results from the body’s ineffective use of insulin that it produces. 
• Gestational diabetes (GDM): It is a type of diabetes that consists of high blood glucose during pregnancy and is associated with complications for both mother and child.