TLR 7/8

March 1, 2021

The Indian Institute of Chemical Technology (IICT), a Council for Scientific and Industrial Research (CSIR) lab helped in the development of key molecule for Covaxin, the indigenous vaccine developed by the city-based Bharat Biotech International Limited.


  • The vaccine is a highly purified, whole virion, inactivated SARS-Cov-2.

  • The vaccine has been formulated with ‘Algel-IMDG’, which contains chemically absorbed TLR7/8 as an agonist or an adjuvant onto aluminium hydroxide gel to generate the requisite type of immune responses without damaging the body.

  • The firm had approached the IICT to develop the synthetic route for the adjuvant molecule TLR 7/8 with indigenous chemicals at an affordable price and with highest purity.

  • This indigenously developed molecule aided Bharat Biotech to scale up the production of the adjuvant.

Source : The Hindu