World Health Organisation (WHO) Global TB Programme has included an Indian Molecular assay TrueNat as initial test for TB and MDR-TB in view of its high diagnostic accuracy, in the rapid communication document.
About:
What is it? The TrueNat TB test is a new molecular test that can diagnosis TB in one hour as well as testing for resistance to the drug rifampicin.
Who has developed it? The TrueNat test has been developed by the Indian firm MolBio Diagnostics Pvt Ltd Goa. It’s development has been funded by Bigtec Labs, India.
Working? The test works by the rapid detection of TB bacteria using the polymerase chain reaction (PCR) technique. Any resistance to rifampicin (RR) is detected by doing a second RTPCR (Reverse transcription polymerase chain reaction)
Genexpert versus TruNat? The Genexpert machine is designed for larger volumes and needs a reliable electricity supply. The TrueNat machine is more of a point of care machine, which is not fully automated. It is designed for situations where there may not be electricity and where the need is for one test to be done at a time.
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