What are Kindlins?

About Kindlins:

• These are adapter proteins that exist inside the cells attached to the cell membranes of almost all types of cells in vertebrates. 
• The Kindlin family of proteins contains three members: Kindlin 1, 2, 3 with distinct amino acid sequences and tissue distribution. 

• They transfer extracellular mechanical cues to biochemical signals inside the cells and play a pivotal role in conveying extracellular signals by physically interacting with structural proteins, receptors and transcription factors, triggering a cascade of chemical signals within the cell.

• Structural disruptions in these proteins can have a global impact on mechano chemical signaling, leading to disruptions in the state of balance among all the body systems needed for the body to survive and function correctly. 
• Kindlins may undergo mutations under the influence of innumerable chemical and physical carcinogens like nicotine, ultraviolet rays and many more. 
• Mutated Kindlin can potentially disrupt global mechanical homeostasis within cells.