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What is Antiphospholipid Syndrome (APS)?

Nov. 19, 2025

A 29-year-old man with a rare autoimmune condition, antiphospholipid syndrome, survived a second stroke and simultaneous clots in his heart and leg after a coordinated emergency intervention at a Chennai city hospital.

About Antiphospholipid Antibody Syndrome (APS):

  • It is a rare autoimmune condition in which the immune system mistakenly makes certain abnormal antibodies that attack tissues in the body.
  • These antibodies target proteins attached to fat molecules (phospholipids), which makes the blood more likely to clot.
  • APS can cause blood clots to form in arteries and veins.
    • Blood clots can form in the legs, lungs, and other organs, such as the kidneys and spleen.
    • The clots can lead to heart attack, stroke, and other conditions.
  • During pregnancy, APS also can result in miscarriage and stillbirth.
  • Some people who have the antibodies may not have any symptoms.
  • There's no cure for this uncommon condition, but medicines can reduce the risk of blood clots and miscarriage.
  • It is more common in women than in men.
  • Having another autoimmune condition, such as systemic lupus erythematosus or other connective tissue diseases, increases the risk of APS.

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