About Cellular Senescence:
- It refers to a state of stable cell cycle arrest in which proliferating cells become resistant to growth-promoting stimuli, typically in response to DNA damage.
- During this phase, the cell undergoes numerous phenotypic and metabolic changes.
- Senescent cells accumulate during ageing and have been implicated in promoting a variety of age-related diseases.
- Cellular senescence can compromise tissue repair and regeneration, thereby contributing towards ageing.
- Removal of senescent cells can attenuate age-related tissue dysfunction and extend health span.
- Senescence can also act as a potent anti-tumour mechanism by preventing the proliferation of potentially cancerous cells.
