What is Cellular Senescence?

About Cellular Senescence:

• It refers to a state of stable cell cycle arrest in which proliferating cells become resistant to growth-promoting stimuli, typically in response to DNA damage. 
• During this phase, the cell undergoes numerous phenotypic and metabolic changes.
• Senescent cells accumulate during ageing and have been implicated in promoting a variety of age-related diseases.
• Cellular senescence can compromise tissue repair and regeneration, thereby contributing towards ageing.
• Removal of senescent cells can attenuate age-related tissue dysfunction and extend health span.
• Senescence can also act as a potent anti-tumour mechanism by preventing the proliferation of potentially cancerous cells.