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What is Crimean-Congo Hemorrhagic Fever (CCHF)?

Aug. 24, 2026

Scientists recently identified multiple targets for antibodies, proteins that protect when an unwanted substance enters body that, could help treat Crimean-Congo hemorrhagic fever (CCHF).

About Crimean-Congo Hemorrhagic Fever (CCHF):

  • It is an important zoonotic disease caused by a tick-borne virus (Nairovirus) belonging to the family Bunyaviridae.
  • The CCHF virus causes severe viral haemorrhagic fever outbreaks, with a case fatality rate of 10–40%.
  • Distribution:
    • The disease was first characterized in 1944 in the Crimea.
    • In 1969, the same pathogen was identified as the cause of a similar disease in the Democratic Republic of the Congo, leading to the combined name used today.
    • CCHF commonly spreads in (is endemic to) Africa, Asia, the Middle East, and parts of Europe.
    • Its distribution closely mirrors that of Hyalomma ticks, the primary vectors responsible for transmitting the virus.
  • Transmission:
    • It is transmitted by bites from infected ticks or by direct contact with blood or tissues of infected ticks, people, and livestock.
    • The ticks can also be hosted by migratory birds.
    • People working in livestock industries, slaughterhouses, and veterinary services are considered among the highest-risk groups for infection.
  • Treatment:
    • There is no specific treatment or cure for CCHF.
    • Supportive care includes fluid balance, giving oxygen, managing blood pressure, and treating other infections.
    • An antiviral called Ribavirin has shown some benefits in treating CCHF patients.

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