What is Frontotemporal Dementia (FTD)?

Dec. 16, 2023

A protein named TAF15 present in the brains of patients suffering from frontotemporal dementia (FTD) has been recently identified by an international team of researchers, which opens up a new target for possible treatments for FTD.

About Frontotemporal Dementia (FTD):

  • FTD is an uncommon type of dementia that causes problems with behaviour and language.
  • Dementia is the name for problems with mental abilities caused by gradual changes and damage to the brain.
  • FTD affects the front and sides of the brain (the frontal and temporal lobes).
  • Causes:
    • The cause of FTD is unknown.
    • Researchers have linked certain subtypes of FTD to mutations in several genes.
    • Some people with FTD have tiny structures, called Pick bodies, in their brain cells. Pick bodies contain an abnormal amount or type of protein.
  • Dementia mostly affects people over 65, but FTD tends to start at a younger age. Most cases are diagnosed in people aged 45-65, although they can also affect younger or older people.
  • Like other types of dementia, FTD tends to develop slowly and get gradually worse over several years.
  • Symptoms:
    • personality and behaviour changes
    • language problems
    • problems with mental abilities
    • memory problems
    • There may also be physical problems, such as slow or stiff movements, loss of bladder or bowel control (usually not until later on), muscle weakness, or difficulty swallowing.
  • Treatment:
    • There's currently no cure for FTD or any treatment that will slow it down.
    • But there are treatments that can help control some of the symptoms, possibly for several years.

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