A multicenter study recently found that the addition of prednisolone to the conventional primary therapy for Kawasaki disease had no effect on lowering the number of cases of coronary-artery lesions at one month from the onset of the disease.
About Kawasaki Disease:
Kawasaki Disease, also known as Kawasaki syndrome or mucocutaneous lymph node syndrome, is a rare disease that causes fever and inflammation of the blood vessels.
It occurs mostly in children younger than 5 years old and affects boys more often than girls.
The disease was first described in Japan by Tomisaku Kawasaki in 1967, and the first cases outside of Japan were reported in Hawaii in 1976.
The cause of Kawasaki disease is unknown, although more cases happen in late winter and early spring.
It is the most common form of acquired (not present at birth) heart disease in children in developed countries.
The condition causes the immune system to attack blood vessels, which become inflamed and swollen.
It tends to affect the coronary arteries, which carry blood to the heart muscle.
It can also cause problems with lymph nodes, skin, and the lining of a child’s mouth, nose, and throat.
It is not contagious, so it cannot spread from person to person.
Symptoms: Symptoms of Kawasaki disease can appear in two phases and may last several weekCommon symptoms include:
A high fever lasting more than five days.
A rash on the main part of the bodyor in the genital area.
An enlarged lymph node in the neck.
Very red eyes without a thick discharge.
Red, dry, cracked lips and a red, swollen tongue.
Swollen, red skin on the palms of the hands and the soles of the feet. Later the skin on fingers and toes peels.
Treatment:
It is often treatable. With early treatment, most children get better and have no long-lasting problems.
It is usually treated in the hospital with an intravenous (IV) dose of immunoglobulin (IVIG) antibodies.
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