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What is Kawasaki Disease?

April 27, 2026

A multicenter study recently found that the addition of prednisolone to the conventional primary therapy for Kawasaki disease had no effect on lowering the number of cases of coronary-artery lesions at one month from the onset of the disease.

About Kawasaki Disease:

  • Kawasaki Disease, also known as Kawasaki syndrome or mucocutaneous lymph node syndrome, is a rare disease that causes fever and inflammation of the blood vessels.
  • It occurs mostly in children younger than 5 years old and affects boys more often than girls.
  • The disease was first described in Japan by Tomisaku Kawasaki in 1967, and the first cases outside of Japan were reported in Hawaii in 1976.
  • The cause of Kawasaki disease is unknown, although more cases happen in late winter and early spring.
  • It is the most common form of acquired (not present at birth) heart disease in children in developed countries.
  • The condition causes the immune system to attack blood vessels, which become inflamed and swollen.
  • It tends to affect the coronary arteries, which carry blood to the heart muscle.
  • It can also cause problems with lymph nodes, skin, and the lining of a child’s mouth, nose, and throat.
  • It is not contagious, so it cannot spread from person to person.
  • Symptoms: Symptoms of Kawasaki disease can appear in two phases and may last several week Common symptoms include:
    • A high fever lasting more than five days.
    • A rash on the main part of the body or in the genital area.
    • An enlarged lymph node in the neck.
    • Very red eyes without a thick discharge.
    • Red, dry, cracked lips and a red, swollen tongue.
    • Swollen, red skin on the palms of the hands and the soles of the feet. Later the skin on fingers and toes peels.
  • Treatment:
    • It is often treatable. With early treatment, most children get better and have no long-lasting problems.
    • It is usually treated in the hospital with an intravenous (IV) dose of immunoglobulin (IVIG) antibodies.

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