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What is Lymphedema?

Feb. 19, 2026

A newly discovered cellular mechanism shows promise for treating painful lymphedema.

About Lymphedema:

  • It is swelling in various areas of body that happens when something affects the lymphatic system.
  • The lymphatic system collects excess fluid, proteins, and toxins from the cells and tissues and returns them to the bloodstream.
  • When the lymphatic system doesn’t work well, the body accumulates fluid and may begin to swell.
  • The swelling typically affects the arms and legs, but it can affect other areas of the body, too.
  • Causes:
    • Lymphedema can happen after certain surgeries or because of certain medical conditions or genetic conditions.
    • It can be caused by cancer treatments that remove or damage the lymph nodes.
    • One may develop lymphedema spontaneously, meaning it happens for no known reason.
  • Symptoms:
    • Lymphedema symptoms may be mild, causing minor swelling and discomfort.
    • Severe cases of lymphedema can affect the ability to move the affected limb, increase the risks of skin infections and sepsis, and can lead to skin changes and breakdown.
  • Treatment:
    • Once lymphedema develops, it is a chronic condition that cannot be cured but can be treated to relieve swelling and improve the ability to function day to day.

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