Striking at the heart of antimicrobial resistance, the international NeoSep 1 trial to evaluate life-saving antibiotic combinations for newborns with sepsis has expanded to India, with the first baby being recruited at the JIPMER in Puducherry.
About Neonatal Sepsis:
It is a life-threatening bloodstream infection that occurs in babies under 90 days old, often affecting premature or low-birth-weight infants.
It is one of the leading causes of neonatal mortality in the world, taking 30% to 50% of babies’ lives.
Cause:
Bacterial infections are the most common cause of neonatal sepsis.
It can be caused by bacteria such as Escherichia coli (E coli), Listeria, and some strains of streptococcus.
The herpes simplex virus (HSV) can also cause a severe infection in a newborn baby. This happens most often when the mother is newly infected with HSV.
Classification:
Early-onset sepsis (EOS):
It presents at or before 72 hours of life.
The source of infection has been traditionally believed to be the maternal genital tract.
Late-onset sepsis (LOS):
It presents after 72 hours of life.
LOS can be either healthcare-associated (HAI) or community-acquiredinfection.
Treatment:
Sepsis in newborns is curable.
It must be treated in a hospital, usually through antibiotics transmitted intravenously.
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