What is the Oral Glucose Tolerance Test (OGTT)?

June 29, 2024

Researchers from India, London and Africa have proposed that the oral glucose tolerance test (OGTT) used to determine if a pregnant woman has developed gestational diabetes be replaced by an HbA1c test.

About Oral Glucose Tolerance Test (OGTT):

  • OGTTs are done to measure how well the body can process large amounts of sugar
  • Procedure:
    • The person fasts overnight, and in the morning, is given a fixed dose of glucose, usually in the form of a sweet drink.
    • Blood samples are taken at 30-minute intervals for 2 hours.
  • If the blood sugar reading is above a certain level, this could be a sign that sugar is not being absorbed fast enough by the body’s organs. 
  • Then diabetes, or gestational (pregnancy-related) diabetes, might be at the root of this problem.
  • In gestational diabetes, blood sugar levels are often higher due to changes in the metabolism during pregnancy, but they usually come back down again after the child is born.
  • Diabetes can lead to heart disease, nerve damage, eye disease, and kidney damage.

What is the HbA1c test?

  • A hemoglobin A1C (HbA1C) test is a blood test that shows what your average blood sugar (glucose) level was over the past two to three months.
  • Glucose in your blood sticks to hemoglobin, a protein in your red blood cells (RBCs).
  • As your blood glucose levels increase, more of your hemoglobin will be coated with glucose.
  • HbA1c is what’s known as glycated haemoglobin.
  • An HbA1c test measures the percentage of your RBCs that have glucose-coated hemoglobin.
  • RBCs are active for around 2-3 months, which is why the reading is taken quarterly.
  • No preparation is needed for this test.
  • A high HbA1c means you have too much sugar in your blood.

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